Passive Transfer of Transplantation Immunity

@article{Mitchison1953PassiveTO,
  title={Passive Transfer of Transplantation Immunity},
  author={Neil Mitchison},
  journal={Nature},
  year={1953},
  volume={171},
  pages={267-268}
}
PASSIVE transfer of transplantation immunity has never been successfully achieved in a simple way. Previous demonstrations of passive transfer have either employed special techniques giving results which are difficult to interpret1,2, or else the nature of the immunity has been in doubt3. Here is reported a simple procedure for passively transferring transplantation immunity to a tumour. 
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96 Citations
Highly Influential Citations
3
Background Citations
15
Methods Citations
1
Results Citations
1

96 Citations

Citation Type

Citation Type

PASSIVE TRANSFER OF TRANSPLANTATION IMMUNITY
TLDR
It appeared that the homograft reaction and delayed sensitivity of tuberculin type were achieved by different immunologic mechanisms within the same species.
Cellular Fixed Antibodies in Transplantation Immunity
TLDR
The binding of tissue antigen to lymph-node cells of sensitized animals can be demonstrated in vitro by the decrease of antigen content in solution.
Transplantation tolerance from a historical perspective
TLDR
The view of the concepts of allograft acceptance and acquired tolerance from a historical perspective are presented, and an attempt is made to amalgamate them into simple and unifying rules that might guide improvements in clinical therapy.
Mechanisms of transplantation immunity
  • E. Simpson
  • Biology, Medicine
    Springer Seminars in Immunopathology
  • 2004
TLDR
This chapter describes the biology and genetics of the major and minor histocompatibility antigens and the nature of in vitro and in vivo immune responses to them and to tissue-specificAntigens in adult animals, including man.
Cell-Mediated Tumor Allograft Immunity: In vitro Transfer with RNA
TLDR
The migration inhibitory effect of A/J lymph mode antigens was transferable to normal C57B1/6J spleen cells by RNA extracted from lymph nodes and spleens of immunized animals.
Immune Tolerance and Rejection in Organ Transplantation.
TLDR
The history of transplantation, the multiple cell types, and mechanisms that are involved in rejection and tolerance of a transplanted organ are described, as well as the common and promising new therapeutics used in transplant patients are summarized.
Passive Transfer of a Tumour-resistant Agent by Serum Injections
TLDR
The question of passive transfer of tumour resistance (or immunity) appears still open and the status of vaccination as a source of immunity is still open.
HUMORAL FACTORS IN CANINE RENAL ALLOGRAFT REJECTION
Fundamentals in homotransplantation.
  • C. Marks
  • Medicine
    Postgraduate medical journal
  • 1966
TLDR
Vigorous and energetic clinical and laboratory investigation will undoubtedly solve many aspects of the immune responses by recipients of transplants, as well as regarding methods of suppression of these immune responses.
Cytotoxic T Lymphocytes: Mechanism of Action and Role in Allograft Rejection
TLDR
The discovery of cytotoxic T lymphocytes emerged from attempts to understand the basis for tumor immunity, delayed-type hypersensitivity (DTH) reactions, and especially allograft rejection, and it was concluded that transplant rejection was caused by contact-mediated destruction of graft cells induced by immune cells, rather than soluble molecules.
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References

SHOWING 1-6 OF 6 REFERENCES
Absorption of the Protective Agent from Rats Resistant to a Transplantable Sarcoma
TLDR
The almost innumerable attempts to discover a protective agent need not be discussed here for they have been already reviewed, nor need the more recent investigations of Lumsden be considered, since a situation complex enough as it stands has been made still more difficult by the introduction of a foreign species.
Experiments on Transfer of Cutaneous Sensitivity to Simple Compounds
TLDR
There is preliminary evidence that moderate heating sufficient to kill the exudate cells abolishes the effect, and one would be inclined to assume that the sensitivity is produced by an activity in the recipient of the surviving cells, if not by antibodies carried by these.
Transfer of Acquired Resistance to Transplantable Leukemia in Mice.∗
TLDR
These preliminary results demonstrate that resistance to a transplantable leukemia may be transferred from cell-immunized mice to normal mice by implantation of tissue from actively immunized mice.
The Cellular Transfer of Cutaneous Hypersensitivity to Tuberculin
TLDR
Experiments show that guinea pigs receiving such cells acquire for a limited time a skin hypersensitivity that exhibits the essential features of the typical tuberculin reaction.
Parabiosis and resistance to transplantation; studies on the resistance to transmissible leukemia in mice by means of heterogenetic and homogenetic parabiosis.
Lymphoid Tumors in Mice Receiving Steroid Hormones