Passive Surveillance for Azole-Resistant Aspergillus fumigatus, United States, 2011–2013

@inproceedings{Pham2014PassiveSF,
  title={Passive Surveillance for Azole-Resistant Aspergillus fumigatus, United States, 2011–2013},
  author={Cau Dinh Pham and E. Rei\ss and Ferry Hagen and Jacques F Meis and Shawn R. Lockhart},
  booktitle={Emerging infectious diseases},
  year={2014}
}
Emergence of Aspergillus fumigatus strains containing mutations that lead to azole resistance has become a serious public health threat in many countries. Nucleotide polymorphisms leading to amino acid substitutions in the lanosterol demethylase gene (cyp51A) are associated with reduced susceptibility to azole drugs. The most widely recognized mutation is a lysine to histidine substitution at aa 98 (L98H) and a duplication of the untranscribed promoter region, together known as TR34/L98H. This… CONTINUE READING