Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.

Abstract

We have analyzed somatic hypermutation in mice carrying an immunoglobulin kappa transgene in order to discriminate mutations that reflect the intrinsic specificity of the hypermutation mechanism from those highlighted by antigenic selection. We have immunized animals with three different immunogens. With one immunogen, the antigen-specific B cells express a… (More)

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@article{Betz1993PassengerTR, title={Passenger transgenes reveal intrinsic specificity of the antibody hypermutation mechanism: clustering, polarity, and specific hot spots.}, author={Alexander Betz and Codrina Rada and Roger D. Pannell and Claudio F Milstein and Michael S. Neuberger}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1993}, volume={90 6}, pages={2385-8} }