Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism

@inproceedings{Pande2013PassageTT,
  title={Passage through the mammalian gut triggers a phenotypic switch that promotes Candida albicans commensalism},
  author={Kalyan Pande and Changbin Chen and Suzanne M. Noble},
  booktitle={Nature Genetics},
  year={2013}
}
Among ∼5,000,000 fungal species, C. albicans is exceptional in its lifelong association with humans, either within the gastrointestinal microbiome or as an invasive pathogen. Opportunistic infections are generally ascribed to defective host immunity but may require specific microbial programs. Here we report that exposure of C. albicans to the mammalian gut triggers a developmental switch, driven by the Wor1 transcription factor, to a commensal cell type. Wor1 expression was previously observed… CONTINUE READING
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