Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.

Abstract

Saccharomyces cerevisiae mother cells undergo an aging program that includes morphologic changes, sterility, redistribution of the Sir transcriptional silencing complex from HM loci and telomeres to the nucleolus, alterations in nucleolar architecture, and accumulation of extrachromosomal ribosomal DNA circles (ERCs). We report here that cells starved for… (More)

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@article{Ashrafi1999PassageTS, title={Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae.}, author={Kaveh Ashrafi and D. Sinclair and J. I. Gordon and Lenny Guarente}, journal={Proceedings of the National Academy of Sciences of the United States of America}, year={1999}, volume={96 16}, pages={9100-5} }