Passage of classical swine fever virus in cultured swine kidney cells selects virus variants that bind to heparan sulfate due to a single amino acid change in envelope protein E(rns).

@article{Hulst2000PassageOC,
  title={Passage of classical swine fever virus in cultured swine kidney cells selects virus variants that bind to heparan sulfate due to a single amino acid change in envelope protein E(rns).},
  author={Marcel Hulst and H. G. P. van Gennip and Rob J. M. Moormann},
  journal={Journal of virology},
  year={2000},
  volume={74 20},
  pages={
          9553-61
        }
}
Infection of cells with Classical swine fever virus (CSFV) is mediated by the interaction of envelope glycoprotein E(rns) and E2 with the cell surface. In this report we studied the role of the cell surface glycoaminoglycans (GAGs), chondroitin sulfates A, B, and C (CS-A, -B, and -C), and heparan sulfate (HS) in the initial binding of CSFV strain Brescia to cells. Removal of HS from the surface of swine kidney cells (SK6) by heparinase I treatment almost completely abolished infection of these… CONTINUE READING

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Microbial adherence to and invasion through proteoglycans.

  • Infection and immunity
  • 1997
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Molecular cloning and nucleotide sequence of hog cholera virus strain Brescia and mapping of the genomic region encoding envelope protein

Moormann, M R.J., +4 authors M. M. Hulst
  • Virology
  • 1990
VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL