Parvovirus B19 uptake is a highly selective process controlled by VP1u, a novel determinant of viral tropism.

@article{Leisi2013ParvovirusBU,
  title={Parvovirus B19 uptake is a highly selective process controlled by VP1u, a novel determinant of viral tropism.},
  author={Remo Leisi and Nico Ruprecht and Christoph Kempf and Carlos Teod{\'o}sio Da Ros},
  journal={Journal of virology},
  year={2013},
  volume={87 24},
  pages={13161-7}
}
The VP1 unique region (VP1u) of human parvovirus B19 (B19V) is the immunodominant part of the viral capsid. Originally inaccessible, the VP1u becomes exposed upon primary attachment to the globoside receptor. To study the function of the exposed VP1u in B19V uptake, we expressed this region as a recombinant protein. Here, we report that purified recombinant VP1u binds and is internalized in UT7/Epo cells. By means of truncations and specific antibodies, we identified the most N-terminal amino… CONTINUE READING