Parvovirus B19-specific DNA in bone marrow from B19 arthropathy patients: evidence for B19 virus persistence.

@article{Foto1993ParvovirusBD,
  title={Parvovirus B19-specific DNA in bone marrow from B19 arthropathy patients: evidence for B19 virus persistence.},
  author={Forskningsr{\aa}det Foto and Kenneth G. Saag and L L Scharosch and E J Howard and Stanley J. Naides},
  journal={The Journal of infectious diseases},
  year={1993},
  volume={167 3},
  pages={744-8}
}
To determine if B19 infection persists in patients with chronic B19 arthropathy, acute B19 infection in adults was documented by IgM serology. Bone marrow aspirates were obtained 24-42 months after acute infection in 4 patients who developed chronic joint symptoms. DNA from bone marrow aspirates was amplified by polymerase chain reaction by using B19-specific DNA sequences in the viral capsid gene and probing with B19-specific oligonucleotides in Southern analysis. B19-specific DNA sequences… CONTINUE READING
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