Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis

@inproceedings{Poole2011ParvovirusBN,
  title={Parvovirus B19 Nonstructural Protein-Induced Damage of Cellular DNA and Resultant Apoptosis},
  author={Brian D. Poole and Violetta Kivovich and L Gilbert and Stanley J. Naides},
  booktitle={International journal of medical sciences},
  year={2011}
}
Parvovirus B19 is a widespread virus with diverse clinical presentations. The viral nonstructural protein, NS1, binds to and cleaves the viral genome, and induces apoptosis when transfected into nonpermissive cells, such as hepatocytes. We hypothesized that the cytotoxicity of NS1 in such cells results from chromosomal DNA damage caused by the DNA-nicking and DNA-attaching activities of NS1. Upon testing this hypothesis, we found that NS1 covalently binds to cellular DNA and is modified by PARP… CONTINUE READING
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