We explore the physics of the parton-hadron duality in the nucleon structure functions appearing in lepton-nucleon scattering. We stress that the duality allows one to extract the higher-twist matrix elements from data in the resonance region, and learn about the properties of resonances if these matrix elements are known. As an example, we construct the moments of F2(x,Q 2) for the low and medium Q2 region, and from which we study the interplay between higher twists and the resonance contributions. Typeset using REVTEX This work is supported in part by funds provided by the U.S. Department of Energy (D.O.E.) under cooperative agreement #DF-FC02-94ER40818.