Partners in crime: ubiquitin-mediated degradation and autophagy.


Recent focus on autophagy research has led to new insights on the involvement of ubiquitin (Ub)-mediated signaling as a selectivity factor in autophagy, which is generally considered a nonselective global degradation system. Emerging reports have demonstrated active crosstalk between the Ub-dependent proteolytic system and autophagy. This article highlights recent reports describing Ub-mediated selective autophagy regulated by the Toll-like receptor 4-induced immune response.

DOI: 10.1126/scisignal.2002052

Cite this paper

@article{Sriram2011PartnersIC, title={Partners in crime: ubiquitin-mediated degradation and autophagy.}, author={Shashikanth M. Sriram and Dong Hoon Han and Sung Tae Kim}, journal={Science signaling}, year={2011}, volume={4 178}, pages={jc4} }