Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer.

@article{Knudsen2010PartnersIC,
  title={Partners in crime: deregulation of AR activity and androgen synthesis in prostate cancer.},
  author={Karen E. Knudsen and Trevor M Penning},
  journal={Trends in endocrinology and metabolism: TEM},
  year={2010},
  volume={21 5},
  pages={315-24}
}
Prostate cancer remains a leading cause of cancer death, as there are no durable means to treat advanced disease. Treatment of non-organ-confined prostate cancer hinges on its androgen dependence. First-line therapeutic strategies suppress androgen receptor (AR) activity, via androgen ablation and direct AR antagonists, whereas initially effective, incurable, 'castration-resistant' tumors arise as a result of resurgent AR activity. Alterations of AR and/or associated regulatory networks are… CONTINUE READING