Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style.

@article{Zhu2010PartlyPP,
  title={Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style.},
  author={Saijie Zhu and Minghuang Hong and Guotao Tang and Lili Qian and Jiayuan Lin and Yanyan Jiang and Yuanying Pei},
  journal={Biomaterials},
  year={2010},
  volume={31 6},
  pages={1360-71}
}
Partly PEGylated polyamidoamine (PAMAM) dendrimers were used as the carrier for tumor-selective targeting of the anticancer drug doxorubicin (DOX). Acid-sensitive cis-aconityl linkage or acid-insensitive succinic linkage was introduced between DOX and polymeric carriers to produce PPCD or PPSD conjugates, respectively. DOX release from PPCD conjugates followed an acid-triggered manner and increased with increasing PEGylation degree. In vitro cytotoxicity of PPCD conjugates against murine B16… CONTINUE READING
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