Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene.

@article{Serluca2001PartitioningOT,
  title={Partitioning of tissue expression accompanies multiple duplications of the Na+/K+ ATPase alpha subunit gene.},
  author={Fabrizio C. Serluca and Arend Sidow and John D. Mably and Mark C Fishman},
  journal={Genome research},
  year={2001},
  volume={11 10},
  pages={1625-31}
}
Vertebrate genomes contain multiple copies of related genes that arose through gene duplication. In the past it has been proposed that these duplicated genes were retained because of acquisition of novel beneficial functions. A more recent model, the duplication-degeneration-complementation hypothesis (DDC), posits that the functions of a single gene may become separately allocated among the duplicated genes, rendering both duplicates essential. Thus far, empirical evidence for this model has… CONTINUE READING