Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT.

@article{Hovorka2002PartitioningGD,
  title={Partitioning glucose distribution/transport, disposal, and endogenous production during IVGTT.},
  author={Roman Hovorka and Fariba Shojaee-Moradie and Paul V. Carroll and Ludovic J. Chassin and Ian J Gowrie and Nicola C. Jackson and Romulus S Tudor and A. Margot Umpleby and Richard Hayden Jones},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2002},
  volume={282 5},
  pages={E992-1007}
}
We have separated the effect of insulin on glucose distribution/transport, glucose disposal, and endogenous production (EGP) during an intravenous glucose tolerance test (IVGTT) by use of a dual-tracer dilution methodology. Six healthy lean male subjects (age 33 +/- 3 yr, body mass index 22.7 +/- 0.6 kg/m(2)) underwent a 4-h IVGTT (0.3 g/kg glucose enriched with 3-6% D-[U-(13)C]glucose and 5-10% 3-O-methyl-D-glucose) preceded by a 2-h investigation under basal conditions (5 mg/kg of D-[U-(13)C… CONTINUE READING
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