Partitioning-Defective 1a/b Depletion Impairs Glomerular and Proximal Tubule Development.

Abstract

The kidney is a highly polarized epithelial organ that develops from undifferentiated mesenchyme, although the mechanisms that regulate the development of renal epithelial polarity are incompletely understood. Partitioning-defective 1 (Par1) proteins have been implicated in cell polarity and epithelial morphogenesis; however, the role of these proteins in… (More)

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