Partition profile of the nicotinic acetylcholine receptor in lipid domains upon reconstitution.

@article{Bermdez2010PartitionPO,
  title={Partition profile of the nicotinic acetylcholine receptor in lipid domains upon reconstitution.},
  author={Vicente Berm{\'u}dez and Silvia Susana Antollini and Gaspar A Fern{\'a}ndez Nievas and Marta I. Avelda{\~n}o and Francisco J. Barrantes},
  journal={Journal of lipid research},
  year={2010},
  volume={51 9},
  pages={2629-41}
}
The nicotinic acetylcholine receptor (AChR) is in intimate contact with the lipids in its native membrane. Here we analyze the possibility that it is the intrinsic properties of the AChR that determine its partition into a given lipid domain. Torpedo AChR or a synthetic peptide corresponding to the AChR M4 segment (the one in closer contact with lipids) was reconstituted into "raft"-containing model membranes. The distribution of the AChR was assessed by Triton X-100 extraction in combination… CONTINUE READING
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