Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.

@article{Wang2012ParticulateMI,
  title={Particulate matter induces cardiac arrhythmias via dysregulation of carotid body sensitivity and cardiac sodium channels.},
  author={Ting Wang and Gabriel D. Lang and Liliana Moreno-Vinasco and Yong Huang and Sascha N. Goonewardena and Ying-jie Peng and Eric C. Svensson and Viswanathan Natarajan and Roberto M. Lang and Jered D. Linares and Patrick N. Breysse and Alison Geyh and Jonathan Matthew Samet and Yves A. Lussier and Samuel Dudley and Nanduri R Prabhakar and Joe Gn Garcia},
  journal={American journal of respiratory cell and molecular biology},
  year={2012},
  volume={46 4},
  pages={524-31}
}
The mechanistic links between exposure to airborne particulate matter (PM) pollution and the associated increases in cardiovascular morbidity and mortality, particularly in people with congestive heart failure (CHF), have not been identified. To advance understanding of this issue, genetically engineered mice (CREB(A133)) exhibiting severe dilated cardiomyopathic changes were exposed to ambient PM collected in Baltimore. CREB(A133) mice, which display aberrant cardiac physiology and anatomy… CONTINUE READING
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