Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect.

@article{Ghio2008ParticulateMI,
  title={Particulate matter in cigarette smoke alters iron homeostasis to produce a biological effect.},
  author={Andrew J Ghio and Elizabeth D. Hilborn and Jacqueline G. Stonehuerner and Lisa A. Dailey and Jacqueline D. Carter and Judy H. Richards and Kay M Crissman and Robert F Foronjy and Dale L Uyeminami and Kent E Pinkerton},
  journal={American journal of respiratory and critical care medicine},
  year={2008},
  volume={178 11},
  pages={1130-8}
}
RATIONALE Lung injury after cigarette smoking is related to particle retention. Iron accumulates with the deposition of these particles. OBJECTIVES We tested the postulate that (1) injury after smoking correlates with exposure to the particulate fraction of cigarette smoke, (2) these particles alter iron homeostasis, triggering metal accumulation, and (3) this alteration in iron homeostasis affects oxidative stress and inflammation. METHODS Rats and human respiratory epithelial cells were… CONTINUE READING
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