Particulate endocytosis mediates biological responses of human mesenchymal stem cells to titanium wear debris.

@article{Okafor2006ParticulateEM,
  title={Particulate endocytosis mediates biological responses of human mesenchymal stem cells to titanium wear debris.},
  author={Chukwuka C Okafor and Hana Haleem-Smith and Patrice Laqueriere and Paul A. Manner and Rocky S Tuan},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2006},
  volume={24 3},
  pages={461-73}
}
Continual loading and articulation cycles undergone by metallic (e.g., titanium) alloy arthroplasty prostheses lead to liberation of a large number of metallic debris particulates, which have long been implicated as a primary cause of periprosthetic osteolysis and postarthroplasty aseptic implant loosening. Long-term stability of total joint replacement prostheses relies on proper integration between implant biomaterial and osseous tissue, and factors that interfere with this integration are… CONTINUE READING
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