Particulate Guanylyl Cyclase A/cGMP Signaling Pathway in the Kidney: Physiologic and Therapeutic Indications

@inproceedings{Chen2018ParticulateGC,
  title={Particulate Guanylyl Cyclase A/cGMP Signaling Pathway in the Kidney: Physiologic and Therapeutic Indications},
  author={Yang Chen and John C. Burnett},
  booktitle={International journal of molecular sciences},
  year={2018}
}
The particulate guanylyl cyclase A (pGC-A)/cGMP pathway plays important roles in regulating renal physiological function and as well as in counteracting pathophysiological conditions. Naturally occurring peptide pGC-A activators consist of atrial natriuretic peptide (ANP), b-type NP (BNP), and urodilatin (URO). These activators bind and activate pGC-A, generating the second messenger cyclic 3',5' guanosine monophosphate (cGMP). Cyclic GMP binds to downstream pathway effector molecules including… CONTINUE READING
0 Citations
57 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-10 of 57 references

Innovative Therapeutics: Designer Natriuretic Peptides

  • L.M.G. Meems, Burnett, J.C.
  • JACC Basic Transl. Sci. 2016,
  • 2016
1 Excerpt

Similar Papers

Loading similar papers…