Particulate β-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression.

@article{Tian2015ParticulateR,
  title={Particulate β-glucan regulates the immunosuppression of granulocytic myeloid-derived suppressor cells by inhibiting NFIA expression.},
  author={Xinyu Tian and Jie Tian and Xinyi Tang and Ke Rui and Yue Zhang and Jie Ma and Yungang Wang and Huaxi Xu and Liwei Lu and Shengjun Wang},
  journal={Oncoimmunology},
  year={2015},
  volume={4 9},
  pages={
          e1038687
        }
}
Myeloid-derived suppressor cells (MDSCs) are a heterogeneous group of cells which comprise two subsets: granulocytic MDSCs (G-MDSCs) and monocytic MDSCs (M-MDSCs). MDSCs involve in tumor-associated immune suppression by remarkably blocking effector T-cell activation and inducing expansion of regulatory T cells in the tumor microenvironment. The treatment that alters the suppression of MDSCs can effectively facilitate the antitumor immune responses. Recently, we showed that the whole β-glucan… CONTINUE READING

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