Particles Resembling Papova Viruses in Human Cerebral Demyelinating Disease

@article{ZuRhein1965ParticlesRP,
  title={Particles Resembling Papova Viruses in Human Cerebral Demyelinating Disease},
  author={Gabriele M. Zu Rhein and S. M. Chou},
  journal={Science},
  year={1965},
  volume={148},
  pages={1477 - 1479}
}
Degenerated brain tissue obtained from a deceased patient who had progressive multifocal leukoencephalopathy had been fixed in formalin prior to processing for electron microscopy. In ultrathin sections virus-like particles resembling papova virions were frequently observed in glial nuclei. Correlation with light-microscopy findings suggests that demyelination resulted from the cytocidal effect of the virus on oligodendroglia. 
Primary progressive multifocal leukoencephalopathy. A central nervous system disease caused by a slow virus.
TLDR
The hypothesis is offered that the disease is caused by a slow virus, not necessarily having an altered immune mechanism as a prerequisite for its propagation, and that altered immunity may provide a more favorable background for its proliferation. Expand
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
Mechanism of demyelination in progressive multifocal leukoencephalopathy (PML) was elucidated by demonstrating ultrastructurally the relationship between the affected glial cells and myelin sheaths.Expand
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Virus-like particles resembling papovaviruses in the brain of one patient and in monkey-kidney cell cultures infected with both virus isolates indicate a close relation between the isolated viruses and SV40. Expand
JC Papovavirus in progressive multifocal leukoencephalopathy.
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Brain tissue from seven patients with progressive multifocal leukoencephalopathy was tested for the presence of papovaviruses and new osolates were indistinguishable from the prototypical JC strain serologically and in all biological characteristics examined. Expand
Viruses and progressive multifocal leukoencephalopathy.
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Demyelinative process associated with atypical intranuclear glial inclusions.
  • L. Langford
  • Biology, Medicine
  • Ultrastructural pathology
  • 1994
TLDR
The morphologic appearance of the inclusions in this case is similar to that described in neuronal intranuclear inclusion disease. Expand
Papovavirus of JC type in progressive multifocal leukoencephalopathy. Rapid identification and subsequent isolation.
TLDR
This second association of JC virus with PML confirms that at least two antigenically distinct viruses may cause PML and demonstrates that methods are now available for the rapid identification of the papovaviruses that may be related to the disease. Expand
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Brain tissue from a patient with progressive multifocal leukoencephalopathy was analyzed by molecular biological and electron-microscopic techniques, and the etiologic agent of PML in this patient was identified without the isolation of infectious virus. Expand
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY
TLDR
The widespread extension of the lesions seemed to correlate with the duration of the patient's illness, and the prolongation of the clinical course may be dependent upon the lack of serious underlying diseases except for a small nodule of thyroid carcinoma, SV40 infection rather than JC virus infection and/or improved care of that kind of patient. Expand
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The clinical features of 15 patients with acquired immune deficiency syndrome (AIDS) and PML who came to autopsy or biopsy between 1983 and 1990 are reviewed, and brain tissue is investigated with conventional and modern molecular biology techniques. Expand
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