Particle size does not affect the rate of intracellular routing for ligands internalized by non-adsorptive pinocytosis.


The rate at which three different species of a fluid phase marker (horseradish peroxidase) reached the lysosomal compartment of mouse LM fibroblasts was compared. Initial observations suggested that the rate was a function of particle size. Adjustment of the concentrations of the various species of HRP to equal numbers of physical particles negated the… (More)


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