Particle-mediated intravascular delivery of oligonucleotides to tumors: associated biology and lessons from genotherapy.

For a solid tumor to become life-threatening, an adequate blood supply has to be established. Although neovascularization has dire consequences for the host, it furnishes a common route through which tumors may be accessed and eradicated by drugs. The fact that a tumor's vasculature is relatively more permeable than that of healthy host tissue means… CONTINUE READING