Particle engineering techniques for inhaled biopharmaceuticals.

@article{Shoyele2006ParticleET,
  title={Particle engineering techniques for inhaled biopharmaceuticals.},
  author={Sunday A Shoyele and Simon Cawthorne},
  journal={Advanced drug delivery reviews},
  year={2006},
  volume={58 9-10},
  pages={1009-29}
}
Formulation of biopharmaceuticals for pulmonary delivery is faced with the challenge of producing particles with the optimal properties for deep lung deposition without altering the native conformation of these molecules. Traditional techniques such as milling are continuously being improved while newer and more advanced techniques such as spray drying, spray freeze drying and supercritical fluid technology are being developed so as to optimize pulmonary delivery of biopharmaceuticals. While… CONTINUE READING

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