Particle diffusional layer thickness in a USP dissolution apparatus II: a combined function of particle size and paddle speed.

@article{Sheng2008ParticleDL,
  title={Particle diffusional layer thickness in a USP dissolution apparatus II: a combined function of particle size and paddle speed.},
  author={Jennifer J Sheng and Paul J Sirois and Jennifer B. Dressman and Gordon L Amidon},
  journal={Journal of pharmaceutical sciences},
  year={2008},
  volume={97 11},
  pages={4815-29}
}
This work was to investigate the effects of particle size and paddle speed on the particle diffusional layer thickness h(app) in a USP dissolution apparatus II. After the determination of the powder dissolution rates of five size fractions of fenofibrate, including <20, 20-32, 32-45, 63-75, and 90-106 microm, the present work shows that the dependence of h(app) on particle size follows different functions in accordance with the paddle speed. At 50 rpm, the function of h(app) is best described… CONTINUE READING

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