Particle clearance and histopathology in lungs of C3H/HeJ mice administered beryllium/copper alloy by intratracheal instillation.

@article{Benson2000ParticleCA,
  title={Particle clearance and histopathology in lungs of C3H/HeJ mice administered beryllium/copper alloy by intratracheal instillation.},
  author={Janet M. Benson and A. M. Holmes and Edward B. Barr and Kristen J Nikula and Thomas H. March},
  journal={Inhalation toxicology},
  year={2000},
  volume={12 8},
  pages={733-49}
}
Beryllium/copper (BeCu) alloys are commonly used in the electronics, automotive, consumer, defense, and aerospace industries. Some individuals exposed occupationally to BeCu alloys have developed chronic beryllium disease. However, little is known of the toxicity and fate of BeCu alloys in the respiratory tract. To begin to address this question, we investigated the pulmonary toxicity and clearance of BeCu alloy (2% Be; 98% Cu) in mice. Groups of 40 female C3H/HeJ mice were administered 12.5… CONTINUE READING