Particle clearance and histopathology in lungs of F344/N rats and B6C3F1 mice inhaling nickel oxide or nickel sulfate.

@article{Benson1995ParticleCA,
  title={Particle clearance and histopathology in lungs of F344/N rats and B6C3F1 mice inhaling nickel oxide or nickel sulfate.},
  author={Janet M. Benson and Ian Yi-Feng Chang and Yung Sung Cheng and Fletcher F. Hahn and Christopher H. Kennedy and Edward B. Barr and Kirk R. Maples and M. B. Snipes},
  journal={Fundamental and applied toxicology : official journal of the Society of Toxicology},
  year={1995},
  volume={28 2},
  pages={232-44}
}
The goals of this study were to (1) determine the effects of repeated inhalation of relatively insoluble nickel oxide (NiO) and highly soluble nickel sulfate hexahydrate (NiSO4.6H2O) on lung particle clearance, (2) investigate the effects of repeated inhalation of NiO or NiSO4 on the pulmonary clearance of subsequently inhaled 85Sr-labeled microspheres, (3) correlate the observed effects on clearance with accumulated Ni lung burden and associated pathological changes in the lung, and (4… CONTINUE READING

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