Particle Surface Roughness Improves Colloidal Stability of Pressurized Pharmaceutical Suspensions

@article{Wang2019ParticleSR,
  title={Particle Surface Roughness Improves Colloidal Stability of Pressurized Pharmaceutical Suspensions},
  author={Hui Wang and David S. Nobes and Reinhard Vehring},
  journal={Pharmaceutical Research},
  year={2019},
  volume={36},
  pages={1-17}
}
PurposeThe effects of particle size and particle surface roughness on the colloidal stability of pressurized pharmaceutical suspensions were investigated using monodisperse spray-dried particles.MethodsThe colloidal stability of multiple suspensions in the propellant HFA227ea was characterized using a shadowgraphic imaging technique and quantitatively compared using an instability index. Model suspensions of monodisperse spray-dried trehalose particles of narrow distributions (GSD < 1.2) and… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Understanding pressurized metered dose inhaler performance.

  • Expert opinion on drug delivery
  • 2015
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

The role of solid nanoparticle technology in the parenteral delivery of poorly water-soluble drugs.

  • International journal of pharmaceutics
  • 2004
VIEW 13 EXCERPTS
HIGHLY INFLUENTIAL

Solid lipid nanoparticles (SLN) for controlled drug delivery - a review of the state of the art.

  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2000
VIEW 12 EXCERPTS
HIGHLY INFLUENTIAL

Intermolecular and Surface Forces

VIEW 3 EXCERPTS
HIGHLY INFLUENTIAL