Particle Size Influences the Immune Response Produced by Hepatitis B Vaccine Formulated in Inhalable Particles

@article{Thomas2010ParticleSI,
  title={Particle Size Influences the Immune Response Produced by Hepatitis B Vaccine Formulated in Inhalable Particles},
  author={Chandan Thomas and Vivek Gupta and Fakhrul Ahsan},
  journal={Pharmaceutical Research},
  year={2010},
  volume={27},
  pages={905-919}
}
To test the hypothesis that particle size influences the magnitude of immune response produced by hepatitis B surface antigen (HBsAg) encapsulated in poly (lactic-co-glycolic acid) (PLGA) microspheres. Microspheres were prepared by a double-emulsion-solvent-evaporation method, and the particles were characterized for size, morphology, porosity and antigen content. Immunogenicity of encapsulated antigen and safety were studied in rats. Uptake of fluorescent-labeled particles by rat alveolar… CONTINUE READING
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