Particle-Based Stochastic Simulation in Systems Biology

  title={Particle-Based Stochastic Simulation in Systems Biology},
  author={Dominic P. Tolle and Nicolas Le Nov{\`e}re},
  journal={Current Bioinformatics},
Computational modeling and simulation have become invaluable tools for the biological sciences. Both aid in the formulation of new hypothesis and supplement traditional experimental research. Many different types of models us- ing various mathematical formalisms can be created to represent any given biological system. Here we review a class of modeling techniques based on particle-based stochastic approaches. In these models, every reacting molecule is repre- sented individually. Reactions… 

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