Participation of two structurally related enzymes in rat hepatic microsomal androstenedione 7 alpha-hydroxylation.

Abstract

Rat hepatic cytochrome P-450 form 3 (testosterone 7 alpha-hydroxylase; P-450 gene IIA1) and P-450 form RLM2 (testosterone 15 alpha-hydroxylase; P-450 gene IIA2) are 88% identical in primary structure, yet they hydroxylate testosterone with distinct and apparently unrelated regioselectivities. In this study, androstenedione and progesterone were used to… (More)

Topics

Cite this paper

@article{Waxman1990ParticipationOT, title={Participation of two structurally related enzymes in rat hepatic microsomal androstenedione 7 alpha-hydroxylation.}, author={David J Waxman and David P. Lapenson and K-i Nagata and Hugh D. Conlon}, journal={The Biochemical journal}, year={1990}, volume={265 1}, pages={187-94} }