Participation of the protein Go in multiple aspects of behavior in C. elegans.

@article{Mendel1995ParticipationOT,
  title={Participation of the protein Go in multiple aspects of behavior in C. elegans.},
  author={Jane E. Mendel and Hendrik C. Korswagen and Katharine S Liu and Yvonne M Hajdu-Cronin and Melvin I. Simon and Ronald H. A. Plasterk and Paul W. Sternberg},
  journal={Science},
  year={1995},
  volume={267 5204},
  pages={1652-5}
}
The goa-1 gene encoding the alpha subunit of the heterotrimeric guanosine triphosphate-binding protein (G protein) Go from Caenorhabditis elegans is expressed in most neurons, and in the muscles involved in egg laying and male mating. Reduction-of-function mutations in goa-1 caused a variety of behavioral defects including hyperactive movement, premature egg laying, and male impotence. Expression of the activated Go alpha subunit (G alpha o) in transgenic nematodes resulted in lethargic… CONTINUE READING
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