Participation of reactive oxygen species in PGF2alpha-induced apoptosis in rat luteal cells.

@article{Tanaka2000ParticipationOR,
  title={Participation of reactive oxygen species in PGF2alpha-induced apoptosis in rat luteal cells.},
  author={Makoto Tanaka and Toshio Miyazaki and Shinji Tanigaki and Kazuhiro Kasai and Kazuhiro Minegishi and Kei Miyakoshi and Hitoshi Ishimoto and Yasunori Yoshimura},
  journal={Journal of reproduction and fertility},
  year={2000},
  volume={120 2},
  pages={239-45}
}
Prostaglandin F(2alpha) (PGF(2alpha)) is implicated in the process of luteal regression in many species. Treatment of rat luteal tissue with PGF(2alpha) increases the generation of reactive oxygen species. Since reactive oxygen species have been implicated in apoptosis, the present study was undertaken to determine whether reactive oxygen species play a role in the PGF(2alpha)-induced apoptosis of rat luteal cells. Rat luteal cells were loaded with 6-carboxy-2, 7'-dichlorodihydro-fluorescein… CONTINUE READING

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