Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase.

@article{Jiang2015ParticipationOP,
  title={Participation of proteasome-ubiquitin protein degradation in autophagy and the activation of AMP-activated protein kinase.},
  author={Shaoning Jiang and Dae Won Park and Yong Gao and Saranya Ravi and Victor M. Darley-Usmar and Edward Abraham and Jaroslaw W Zmijewski},
  journal={Cellular signalling},
  year={2015},
  volume={27 6},
  pages={1186-97}
}
Although activation of the AMP-activated protein kinase (AMPK) as well as of ubiquitin/proteasome degradative pathways play an essential role in the preservation of metabolic homeostasis, little is known concerning interactions between protein turnover and AMPK activity. In the present studies, we found that inhibition of the 26S proteasome resulted in… CONTINUE READING