Participation of p97Eps8 in Src-mediated transformation.

  title={Participation of p97Eps8 in Src-mediated transformation.},
  author={T S Leu and Hsu Hua Yeh and Ching-Chung Huang and Ya-Chun Chuang and Shu Li Su and M C Maa},
  journal={The Journal of biological chemistry},
  volume={279 11},
Histone acetylase and histone deacetylase are two crucial enzymes that determine the structure of chromatin, regulating gene expression. In this study, we observed that trichostatin A (TSA), a specific histone deacetylase inhibitor, could effectively inhibit the growth of v-Src-transformed (IV5) cells and abrogate their ability to form colonies in soft agar. Further analysis demonstrated that, although TSA reduced the expression of Eps8 in a dose- and time-dependent manner, both the protein… CONTINUE READING
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