Participation of p53 cellular tumour antigen in transformation of normal embryonic cells

@article{Eliyahu1984ParticipationOP,
  title={Participation of p53 cellular tumour antigen in transformation of normal embryonic cells},
  author={Daniel Eliyahu and Avraham Raz and P. Gruss and David Givol and Moshe Oren},
  journal={Nature},
  year={1984},
  volume={312},
  pages={646-649}
}
The cellular tumour antigen p53 is found at elevated levels in a wide variety of transformed cells (for reviews see refs 1, 2). Very little is yet known about the precise relationship of p53 to malignant transformation. Although the increase in p53 levels could be a secondary by-product of the transformed state, it is equally possible that p53 is actively involved in altering cellular growth properties, especially as it has been implicated in the regulation of normal cell proliferation3–6. We… CONTINUE READING
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