Participation of ouabainlike compound in reduced renal mass-saline hypertension.

  title={Participation of ouabainlike compound in reduced renal mass-saline hypertension.},
  author={Kazuhiko Yamada and Atsuo Goto and Haruhisa Nagoshi and Chen Hui and Noriko Yagi and Masao Sasabe and Masao Omata},
  volume={23 1 Suppl},
We examined the role of ouabainlike compound in reduced renal mass-saline hypertension using a population of rats immunized with ouabain. To develop ouabain-immunized rats, ouabain-bovine serum albumin conjugates were injected subcutaneously three times at 4-week intervals. Titer determinations were made 2 weeks after the third immunization, and rats with high titers were used in the study. Immunoglobulin G fractions from ouabain-immunized rats effectively inhibited the contractile response of… CONTINUE READING
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