Participation of nitric oxide in the mucosal injury of rat intestine induced by ischemia-reperfusion.

  title={Participation of nitric oxide in the mucosal injury of rat intestine induced by ischemia-reperfusion.},
  author={Kohichi Takada and Kanna Yamashita and Yasuko Sakurai-Yamashita and Kazuto Shigematsu and Yoji Hamada and K Hioki and Kohtaro Taniyama},
  journal={The Journal of pharmacology and experimental therapeutics},
  volume={287 1},
The dual role of nitric oxide as a cytoprotective or a cytotoxic free radical gas has been noted in various types of pathophysiological conditions, including the digestive system. The aim of this study was to examine the role of nitric oxide in the mucosal injury induced by ischemia-reperfusion in the rat small intestine. A transient intestinal ischemia was produced in the catheterized ileal segments of rats by occluding the anterior mesenteric artery for 60 min. Nitric oxide metabolites (NO2… CONTINUE READING


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