Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation

  title={Participation of miR-200a in TGF-β1-mediated hepatic stellate cell activation},
  author={Xu Sun and Yong He and Tao-tao Ma and Chen Huang and Lei Zhang and Jun Li},
  journal={Molecular and Cellular Biochemistry},
Hepatic stellate cell (HSC) activation is a pivotal event in the initiation and progression of hepatic fibrosis since it mediates transforming growth factor beta 1 (TGF-β1)-driven extracellular matrix (ECM) deposition. MicroRNAs (miRNAs), small non-coding RNAs modulating messenger RNA (mRNA) and protein expression, have emerged as key factors to regulate cell proliferation, differentiation, and apoptosis. Although the function of miR-200a has been discussed in many cancers and fibrotic diseases… CONTINUE READING
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