Participation of inorganic phosphate in the chemiosmotic mechanism of mitochondrial energy transduction.

@article{Fony1981ParticipationOI,
  title={Participation of inorganic phosphate in the chemiosmotic mechanism of mitochondrial energy transduction.},
  author={Andr{\'a}s Fony{\'o} and Gergely Luk{\'a}cs and Erzs{\'e}bet Ligeti},
  journal={Acta biologica et medica Germanica},
  year={1981},
  volume={40 7-8},
  pages={907-14}
}
In respiring liver mitochondria in which Pi transport was inhibited and the intramitochondrial Pi value manipulated to vary about 3-fold, K+-ion uptake, H+-ion extrusion and stimulation of respiration were linearly related to the intramitochondrial Pi content. It is suggested that the HPO 2(4)-anion generated during respiration is the nondiffusible anion required for the Donnan distribution and membrane potential in mitochondria. The intramitochondrial H X HPO4-ionic species is the proton donor… CONTINUE READING