Participation of histamine in the step-through active avoidance response and its inhibition by H1-blockers.

@article{Kamei1991ParticipationOH,
  title={Participation of histamine in the step-through active avoidance response and its inhibition by H1-blockers.},
  author={Chiaki Kamei and Kenji Tasaka},
  journal={Japanese journal of pharmacology},
  year={1991},
  volume={57 4},
  pages={473-82}
}
The effects of intravenous and intracerebroventricular administrations of certain H1-blockers on the active avoidance response in rats were studied. Among the classic H1-blockers used in this study: pyrilamine, diphenydramine, promethazine and chlorpheniramine, promethazine was the most effective and chlorpheniramine the least in inhibiting the active avoidance response; namely, a variation of prolongation in the response latency of the avoidance response. Meanwhile, ketotifen most potently… CONTINUE READING