Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs

  title={Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs},
  author={L.C.R. Silva and Thiago Roberto Lima Romero and L S Guzzo and Igor Dimitri Gama Duarte},
  journal={Brazilian Journal of Medical and Biological Research},
  pages={1240 - 1243}
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used extensively to control inflammatory pain. Several peripheral antinociceptive mechanisms have been described, such as opioid system and NO/cGMP/KATP pathway activation. There is evidence that the cannabinoid system can also contribute to the in vivo pharmacological effects of ibuprofen and indomethacin. However, there is no evidence of the involvement of the endocannabinoid system in the peripheral antinociception induced by NSAIDs… 

Figures from this paper

Role of Endocannabinoid System in the Peripheral Antinociceptive Action of Aripiprazole.

These results provide evidence for the involvement of the endocannabinoid system in peripheral antinociception induced by aripiprazole treatment.

Cannabinoid CB1 receptors mediate the effects of dipyrone

Results indicate involvement of the endocannabinoid system, especially CB1 receptors, in the analgesic and cataleptic effects of dipyrone, as well as hypolocomotion, and cannabinoid receptors and TRPV1 were not involved in the hypothermic effects of Dipyrone.

A spider derived peptide, PnPP-19, induces central antinociception mediated by opioid and cannabinoid systems

PnPP-19-induced central antinociception involves theactivation of CB1 cannabinoid, μ- and δ-opioid receptors and Mobilization of endogenous opioids and cannabinoids might be required for the activation of those receptors.

Antinociception produced by nonsteroidal anti-inflammatory drugs in female vs male rats.

It is suggested that common NSAIDs administered shortly after induction of inflammation are more effective in females than males in regard to their antinociceptive effects, whereas their anti-inflammatory effects tend to favor males; effect sizes indicate that sex differences in NSAID effect may be functionally important in some cases.


Iinhibition of cannabinoid receptors does not contribute to the antinociceptive action of systemic diclofenac.

Isobolographic analysis of antinociceptive effect of ketorolac, indomethacin, and paracetamol after simultaneous peripheral local and systemic administration

Analysis of interaction type after simultaneous administration of ketorolac or paracetamol was additive and for indomethacin was synergistic, indicating that the combination of one analgesic drug given simultaneously by two different routes could be an additive or it could lead to a synergistic interaction.

The antipsychotic aripiprazole induces peripheral antinociceptive effects through PI3Kγ/NO/cGMP/KATP pathway activation

The aim of the study was to obtain pharmacological evidence for the involvement of the nitric oxide system in the peripheral antinociceptive effect induced by aripiprazole.


The meta-analysis study of the use of dipyrone in dogs shows the clinical importance of this drug in Brazil, being an effective and safe medication, as long as it is used in the indicated dose of 25 mg/kg.



A role for endocannabinoids in indomethacin-induced spinal antinociception.

Lack of effect of naltrexone on the spinal synergism between morphine and non steroidal anti-inflammatory drugs.

Lack of effect of naltrindole on the spinal synergism of morphine and non-steroidal anti-inflammatory drugs (NSAIDS).

  • H. MirandaG. Pinardi
  • Biology, Medicine
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society
  • 2009
The findings of the present work suggest that the combinations of opioids and non-steroidal anti-inflammatory drugs have a direct action on spinal processing of the nociceptive information, which may achieved by additional mechanisms independent of prostaglandin synthesis inhibition and/or activation of opioid receptors.

Anandamide synthesis is induced by arachidonate mobilizing agonists in cells of the immune system.

Structure of a cannabinoid receptor and functional expression of the cloned cDNA

The cloning and expression of a complementary DNA that encodes a G protein-coupled receptor that is involved in cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana are suggested.

Central antinociception induced by µ‐opioid receptor agonist morphine, but not δ‐ or κ‐, is mediated by cannabinoid CB1 receptor

Whether endocannabinoids are involved in central antinociception induced by activation of µ‐, δ‐ and κ‐opioid receptors is determined.

Cannabinoid physiology and pharmacology: 30 years of progress

Role of endogenous cannabinoids in synaptic signaling.

The synthetic pathways of endocannabinoids are discussed, along with the putative mechanisms of their release, uptake, and degradation, and the fine-grain anatomical distribution of the neuronal cannabinoid receptor CB1 is described in most brain areas, emphasizing its general presynaptic localization and role in controlling neurotransmitter release.

Inhibition of fatty acid amide hydrolase, a key endocannabinoid metabolizing enzyme, by analogues of ibuprofen and indomethacin.