Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs

@article{Silva2012ParticipationOC,
  title={Participation of cannabinoid receptors in peripheral nociception induced by some NSAIDs},
  author={L.C.R. Silva and Thiago Roberto Lima Romero and L S Guzzo and Igor Dimitri Gama Duarte},
  journal={Brazilian Journal of Medical and Biological Research},
  year={2012},
  volume={45},
  pages={1240 - 1243}
}
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been used extensively to control inflammatory pain. Several peripheral antinociceptive mechanisms have been described, such as opioid system and NO/cGMP/KATP pathway activation. There is evidence that the cannabinoid system can also contribute to the in vivo pharmacological effects of ibuprofen and indomethacin. However, there is no evidence of the involvement of the endocannabinoid system in the peripheral antinociception induced by NSAIDs… 

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