Participation of Omi Htra2 Serine-Protease Activity in the Apoptosis Induced by Cisplatin on SW480 Colon Cancer Cells

  title={Participation of Omi Htra2 Serine-Protease Activity in the Apoptosis Induced by Cisplatin on SW480 Colon Cancer Cells},
  author={F. Pruefer and F. Liz{\'a}rraga and V. Maldonado and J. Melendez-Zajgla},
  journal={Journal of Chemotherapy},
  pages={348 - 354}
  • F. Pruefer, F. Lizárraga, +1 author J. Melendez-Zajgla
  • Published 2008
  • Medicine, Biology
  • Journal of Chemotherapy
  • Abstract Apoptosis is triggered by two interconnected pathways, extrinsic and intrinsic. The intrinsic pathway is activated by genomic stress promoting mitochondrial release of apoptotic proteins. One of these proteins is Omi/Htra2, a serine protease which inactivates Inhibitor of Apoptosis Proteins (IAPs). In the present work, we assessed the participation of Omi/Htra2 in the cell death induced by the chemotherapeutic drugs 5-fluorouracil (5-FU) and cisplatin (CDDP) in SW480 colon cancer cells… CONTINUE READING
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