Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation.

@article{Palma2008ParticipationOO,
  title={Participation of OCT3/4 and beta-catenin during dysgenetic gonadal malignant transformation.},
  author={{\'I}cela Palma and Roc{\'i}o Pe{\~n}a and A. Contreras and G. Ceballos-Reyes and N. Coyote and L. Era{\~n}a and S. Kofman‐Alfaro and G. Queipo},
  journal={Cancer letters},
  year={2008},
  volume={263 2},
  pages={
          204-11
        }
}
Gonadoblastoma (GB) is an in situ tumor consisting of a heterogeneous population of mature and immature germ cells, other cells resembling immature Sertoli/granulosa cells, and Leydig/lutein-like cells, may also be present. GB almost exclusively affects a subset of patients with intersex disorders and in 30% of them overgrowth of the germinal component of the tumor is observed and the lesion is term dysgerminoma/seminoma. Several pathways have been proposed to explain the malignant process, and… Expand
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