Participation of K+ channels in the endothelium-dependent and endothelium-independent components of the relaxant effect of rosuvastatin in rat aortic rings.

@article{Lopez2008ParticipationOK,
  title={Participation of K+ channels in the endothelium-dependent and endothelium-independent components of the relaxant effect of rosuvastatin in rat aortic rings.},
  author={Jorge Lopez and Roberto Mendoza and Guadalupe Cleva Villanueva and Gustavo De la Cruz Mart{\'i}nez and Enrique F. Castillo and Carlos Castillo},
  journal={Journal of cardiovascular pharmacology and therapeutics},
  year={2008},
  volume={13 3},
  pages={207-13}
}
Rosuvastatin was tested on rat aortic rings in the presence and absence of K(+) channel blockers, mevalonic acid, and inhibitors of nitric oxide, prostaglandins, or endothelial-derived hyperpolarizing factor synthesis. The direct vascular effects of rosuvastatin were then evaluated by obtaining dose-response curves. Rosuvastatin relaxed aortic rings with and, to a lesser degree, without endothelium. Under both these conditions this effect was partially inhibited by L-NAME, tetraethylammonium… CONTINUE READING