Participation of ATP/ADP antiporter in oleate- and oleate hydroperoxide-induced uncoupling suppressed by GDP and carboxyatractylate.

@article{Khailova2006ParticipationOA,
  title={Participation of ATP/ADP antiporter in oleate- and oleate hydroperoxide-induced uncoupling suppressed by GDP and carboxyatractylate.},
  author={Lyudmila S Khailova and Elena A Prikhodko and Vera I Dedukhova and Elena N Mokhova and Vasily N Popov and Vladimir P. Skulachev},
  journal={Biochimica et biophysica acta},
  year={2006},
  volume={1757 9-10},
  pages={1324-9}
}
In experiments on isolated kidney and liver mitochondria, it is shown that oleate hydroperoxide induces a much smaller increase in the controlled respiration rate and DeltaPsi decrease than the same concentrations of oleate. Palmitate appears to be less efficient than oleate but more efficient than oleate hydroperoxide. In all cases, GDP and CAtr cause some recoupling, CAtr being more effective. Addition of 0.2 mM GDP before CAtr does not prevent further DeltaPsi increase by subsequent CAtr… CONTINUE READING