Participation in cognitively stimulating activities and risk of incident Alzheimer disease.

  title={Participation in cognitively stimulating activities and risk of incident Alzheimer disease.},
  author={Robert S. Wilson and Carlos F Mendes de Leon and Lisa L. Barnes and Julie A. Schneider and Julia L. Bienias and Denis A. Evans and David A. Bennett},
  volume={287 6},
CONTEXT Frequent participation in cognitively stimulating activities has been hypothesized to reduce risk of Alzheimer disease (AD), but prospective data regarding an association are lacking. OBJECTIVE To test the hypothesis that frequent participation in cognitive activities is associated with a reduced risk of AD. DESIGN Longitudinal cohort study with baseline evaluations performed between January 1994 and July 2001 and mean follow-up of 4.5 years. PARTICIPANTS AND SETTING A total of… 

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