Participant expectancies in double-blind randomized placebo-controlled trials: potential limitations to trial validity.

@article{Colagiuri2010ParticipantEI,
  title={Participant expectancies in double-blind randomized placebo-controlled trials: potential limitations to trial validity.},
  author={Ben Colagiuri},
  journal={Clinical trials},
  year={2010},
  volume={7 3},
  pages={
          246-55
        }
}
BACKGROUND Randomized controlled trials (RCTs) that use placebo controls to achieve double-blinding intend to establish the efficacy of a treatment over and above expectancy and other forms of bias. Despite this, a growing body of research suggests that participant expectancies can influence the outcomes of these trials. PURPOSE and METHODS This nonsystematic review examines research assessing the role of participant expectancies in double-blind placebo-controlled RCTs in order to determine… CONTINUE READING

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